The following experimental applications are currently being researched attempting to correct the sexual abberations:

Challenges with the Y chromosome:  The Y chromosome is particularly difficult to repair because it lacks a "partner" chromosome to swap genetic material with during recombination, leading to a buildup of damaging mutations over time. 

Gene therapy potential: Scientists are exploring gene therapy approaches where a healthy copy of a mutated gene could be introduced into cells to replace the damaged one. 

CRISPR technology: CRISPR-Cas9 is a powerful gene editing tool that could potentially be used to precisely target and correct specific mutations on the X and Y chromosomes. 

Ethical considerations: Modifying sex chromosomes raises ethical concerns as it could potentially impact future generations and potentially be used for non-therapeutic purposes.  

  Key risks of chromosome therapy:

Immune response: The body's immune system mighht recognize the viral vector used to deliver the therapeutic gene as a foreign invader, triggering an inflammatory response that can be harmful to the patient.

 Off-target editing: The gene editing tools might accidentally modify other DNA sequences,  causing harmful mutations in healthy cells. 

Insertional mutagenesis: When the therapeutic gene integrates into the patient's genome, it could disrupt important genes, causing cancer.

Delivery complications: Targeting the correct cells with the gene therapy can be difficult, leading to unintended results in other tissues. 

Lack of long-term data:  Gene therapy is a relatively new field, the long-term safety and efficacy of these treatments are not fully understood. 

Factors influencing the risk profile:

Type of vector: Different viral vectors have varyiances levels of specific  potentials for immune reactions.